MDandMe is now on the iOS App Store!
MDandMe logo

Questions or suggestions?

MDandMe is now on the iOS App Store!
MDandMe logo
ABOUT
TeamBlogCareersClinical
SERVICES
FAQCommunityOTC GuideChat
CONTACT
EmailFeedback
Download on the App Store

© 2025 AuxHealth, Inc. d.b.a MDandMe®

Privacy Policy
Terms of Service
Gingivitis can be prevented and reversed. Brush twice daily using fluoride toothpaste, like stannous fluoride 0.454%, and consider an electric toothbrush with oscillating-rotating technology for superior plaque removal. Floss daily to clean between teeth, or supplement with a water flosser for improved efficacy. Use antimicrobial mouthwash twice daily to reduce bacterial load. For advanced cases, professional cleaning, such as scaling and root planing, may be necessary to remove plaque and tartar.
January 9, 2025

Gum Bleeding (Gingivitis) Reversal

Evidence-Based Over-The-Counter Guide

William Shen

William Shen

Co-founder & CPO

See all guides. Have more questions?

Gingivitis is an inflammation of the gums caused by plaque buildup. Professional consensus is that gingivitis can be prevented and reversed with good oral hygiene. If it is not addressed, it can lead to peridontitis and bone destruction.

First-line recommendations:

  • Fluoride toothpaste: Brush twice daily with stannous fluoride 0.454% (0.15% w/v fluoride ion). Crest Pro-Health Gum Detoxify (FDA M021). 

  • Electric toothbrushes: Particularly those with oscillating-rotating (O-R) technology, have been shown to be more effective than manual toothbrushes in reducing plaque and gingivitis. Oral-B Pro Electric Toothbrush (ADA Approved 2017).

  • Flossing: Removes plaque between teeth. Perform once daily. GUM Deep Clean Expanding Dental Floss.

Second-line recommendations:

  • Antimicrobial Mouthwash: Reduces bacterial load. Use after brushing twice daily. Listerine Clinical Solutions Mouthwash.

  • Water flossing: Can be used to supplement or substitute for traditional flossing. May be equally or more effective than physical floss at reducing gingivitis, depending on rigor of use. Waterpik Portable Water Floss (ADA Accepted).

Professional Cleaning: Scaling and root planing may be needed for plaque and tartar removal.

Citations:

Grender, J., Adam, R., & Zou, Y. (2020). The effects of oscillating-rotating electric toothbrushes on plaque and gingival health: a meta-analysis. Am J Dent, 33(1), 3-11.

Stephens, M. B., Wiedemer, J. P., & Kushner, G. M. (2018). Dental problems in primary care. American family physician, 98(11), 654-660.

What OTC evidence is reviewed?

  • For each condition, we performed a literature review to find a recent widely cited expert group guideline published in the leading specialty-specific peer-reviewed journal or top general medical journal.

  • Based on the recommendations in the publication, we identify recommended active ingredients and devices that are available over-the-counter per FDA regulations.

What evidence is prioritized?

Levels of evidence considered:

  • Tier 1 (Safe and Definitely Effective): Professional field consensus or multiple randomized controlled clinical trials showing the same conclusion. Wherever possible, we use Tier 1 evidence for "first-line" recommendations.

  • Tier 2 (Safe and Probably Effective): Individual clinical trials which may be discordant or large-scale observational experience. Tier 2 evidence may inform "first-line", "second-line", or "supplement" recommendations.

  • Tier 3 (Safe and Maybe Effective): Mechanistic plausibility without high-quality clinical evidence of efficacy but high-quality evidence of safety. Tier 3 evidence may inform "second-line" or "supplement" recommendations.

How does MDandMe select recommended products?

  • Based on the top clinical recommendation, we evaluate products containing the recommended active agent with FDA-approved dosage based on price, average customer reviews, how often it is purchased, and how quickly it will ship to home. 

  • We provide public documentation of the active ingredients in our recommendations, using all 32 FDA monographs, Prescription-to-Nonprescription (Rx-to-OTC) Switches, as well as New Drug Application (NDA) approvals.

How does MDandMe select recommended devices?

  • Based on the top clinical recommendation, we evaluate devices that are FDA-cleared or comply with other medical guidelines (if not a FDA-regulated category) by reputability, price, and average customer reviews.

  • We provide public documentation of supporting evidence for each device.  

Where do I view other OTC guides?

Browse topic list here:

  • Acne

  • Acid Reflux

  • Allergies (Nasal)

  • Allergies (Itchy Eyes)

  • Allergic Skin Rash

  • Ankle Sprain

  • Arthritis (Osteoarthritis)

  • Athlete's Foot

  • Back Pain (Lower Back)

  • Bedbugs

  • Birth Control

  • Bloating and Gas

  • Bronchitis

  • Bug and Insect Bites

  • Callus

  • Carpal Tunnel

  • Common Cold

  • Constipation

  • Constipation (Severe)

  • Contact Dermatitis

  • Corns

  • Cough (Chronic Dry Cough)

  • Dandruff

  • Diarrhea

  • Dry Eyes

  • Earwax

  • Eczema

  • GERD

  • Glue Ear

  • Gum Bleeding (Gingivitis)

  • Hair Loss

  • Hay Fever

  • Headache (Tension Headache)

  • Hearing Loss

  • Hemorrhoids

  • High Blood Pressure (Hypertension)

  • Hives

  • Insomnia

  • Irritable Bowel Syndrome (IBS)

  • Lice (Head Lice)

  • Migraines

  • Morning Sickness (Pregnancy)

  • Motion Sickness

  • Nailbed Infection (Acute)

  • Nailbed Infection (Chronic)

  • Nasal Allergies

  • Orthostatic Hypotension

  • Period Pain

  • Peripheral Neuropathy

  • Pinworm

  • Post-Nasal Drip

  • POTS

  • Pregnancy

  • Psoriasis

  • Ringworm

  • Sinusitis

  • Skin Tags

  • Sore Throat

  • Swimmer's Ear

  • Tooth Sensitivity

  • Urinary Incontinence

  • Urinary Tract Infections

  • Urticaria

  • Varicose Veins

  • Venous Insufficiency

  • Vertigo (BPPV)

  • Warts

  • Wrist Pain and Tingling

  • Yeast Infection (Vaginal)

You can view all of our published OTC guides here.

Related Posts
How We Make OTC Guides
How We Make OTC Guides